Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 11 (5)

Modifications of Polymeric Membranes Used in Guided Tissue and Bone Regeneration

Affiliations
Review

Modifications of Polymeric Membranes Used in Guided Tissue and Bone Regeneration

Wojciech Florjanski et al. Polymers (Basel).

Abstract

Guided tissue/bone regeneration (GTR/GBR) is a widely used procedure in contemporary dentistry. To achieve the required results of tissue regeneration, soft tissues that reproduce quickly are separated from the slow-growing bone tissue by membranes. Many types of membranes are currently in use, but none of them fulfil all of the desired features. To address this issue, further research on developing new membranes with better separation characteristics, such as membrane modification, is needed. Many of the current innovative modified materials are still in the phase of in vitro and experimental studies. A collective review on new trends in membrane modification to GTR/GBR is needed due to the widespread use of polymeric membranes and the constant development in the field of dentistry. Therefore, the aim of this review was to present an overview of polymeric membrane modifications to the GTR/GBR reported in the literature. The authors searched databases, including PubMed, SCOPUS, Web of Science, and OVID, for relevant studies that were published during 1999-2019. The following keywords were used: guided tissue regeneration, membranes, coating, and modification. A total of 17 papers were included in this review. Furthermore, the articles were divided into three groups that were based on the type of membrane modification: antibiotic coating, ion-use modifications, and others modifications, thus providing an overview of current existing knowledge in the field and encouraging further research. The results of included studies on modified barrier membranes seem to be promising, both in terms of safety and benefits for patients. However, modifications result in a large spectrum of effects. Further clinical studies are needed on a large group of patients to clearly confirm the effects that were observed in animal and in vitro studies.

Keywords: coating; guided bone regeneration; guided tissue regeneration; membrane; modification.

Conflict of interest statement

The authors declare no conflicts of interest.

Similar articles

See all similar articles

Cited by 1 article

References

    1. Chiapasco M., Zaniboni M. Clinical outcomes of GBR procedures to correct peri-implant dehiscences and fenestrations: A systematic review. Clin. Oral Implants Res. 2009;20(Suppl. 4):113–123. doi: 10.1111/j.1600-0501.2009.01781.x. - DOI - PubMed
    1. Rakhmatia Y.D., Ayukawa Y., Furuhashi A., Koyano K. Current barrier membranes: Titanium mesh and other membranes for guided bone regeneration in dental applications. J. Prosthodont. Res. 2013;57:3–14. doi: 10.1016/j.jpor.2012.12.001. - DOI - PubMed
    1. Hämmerle C.H.F., Jung R.E. Bone augmentation by means of barrier membranes. Periodontology 2000. 2003;33:36–53. doi: 10.1046/j.0906-6713.2003.03304.x. - DOI - PubMed
    1. Dimitriou R., Mataliotakis G.I., Calori G.M., Giannoudis P.V. The role of barrier membranes for guided bone regeneration and restoration of large bone defects: Current experimental and clinical evidence. BMC Med. 2012;10:81 doi: 10.1186/1741-7015-10-81. - DOI - PMC - PubMed
    1. Murphy K.G., Gunsolley J.C. Guided Tissue Regeneration for the Treatment of Periodontal Intrabony and Furcation Defects. A Systematic Review. Ann. Periodontol. 2003;8:266–302. doi: 10.1902/annals.2003.8.1.266. - DOI - PubMed
Feedback