Guided tissue/bone regeneration (GTR/GBR) is a widely used procedure in contemporary dentistry. To achieve the required results of tissue regeneration, soft tissues that reproduce quickly are separated from the slow-growing bone tissue by membranes. Many types of membranes are currently in use, but none of them fulfil all of the desired features. To address this issue, further research on developing new membranes with better separation characteristics, such as membrane modification, is needed. Many of the current innovative modified materials are still in the phase of in vitro and experimental studies. A collective review on new trends in membrane modification to GTR/GBR is needed due to the widespread use of polymeric membranes and the constant development in the field of dentistry. Therefore, the aim of this review was to present an overview of polymeric membrane modifications to the GTR/GBR reported in the literature. The authors searched databases, including PubMed, SCOPUS, Web of Science, and OVID, for relevant studies that were published during 1999-2019. The following keywords were used: guided tissue regeneration, membranes, coating, and modification. A total of 17 papers were included in this review. Furthermore, the articles were divided into three groups that were based on the type of membrane modification: antibiotic coating, ion-use modifications, and others modifications, thus providing an overview of current existing knowledge in the field and encouraging further research. The results of included studies on modified barrier membranes seem to be promising, both in terms of safety and benefits for patients. However, modifications result in a large spectrum of effects. Further clinical studies are needed on a large group of patients to clearly confirm the effects that were observed in animal and in vitro studies.
Keywords: coating; guided bone regeneration; guided tissue regeneration; membrane; modification.
Conflict of interest statement
The authors declare no conflicts of interest.
Recent advances in the development of GTR/GBR membranes for periodontal regeneration--a materials perspective.Dent Mater. 2012 Jul;28(7):703-21. doi: 10.1016/j.dental.2012.04.022. Epub 2012 May 14. Dent Mater. 2012. PMID: 22592164 Review.
Biodegradable Polymer Membranes Applied in Guided Bone/Tissue Regeneration: A Review.Polymers (Basel). 2016 Mar 29;8(4):115. doi: 10.3390/polym8040115. Polymers (Basel). 2016. PMID: 30979206 Free PMC article. Review.
Adsorption and release kinetics of growth factors on barrier membranes for guided tissue/bone regeneration: A systematic review.Arch Oral Biol. 2019 Apr;100:57-68. doi: 10.1016/j.archoralbio.2019.02.006. Epub 2019 Feb 16. Arch Oral Biol. 2019. PMID: 30798032
Clinical study of guided bone regeneration with resorbable polylactide-co-glycolide acid membrane.Odontology. 2018 Jul;106(3):334-339. doi: 10.1007/s10266-018-0349-2. Epub 2018 Feb 10. Odontology. 2018. PMID: 29429055
Current barrier membranes: titanium mesh and other membranes for guided bone regeneration in dental applications.J Prosthodont Res. 2013 Jan;57(1):3-14. doi: 10.1016/j.jpor.2012.12.001. Epub 2013 Jan 21. J Prosthodont Res. 2013. PMID: 23347794 Review.
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Biomaterial-Based Approaches for Regeneration of Periodontal Ligament and Cementum Using 3D Platforms.Int J Mol Sci. 2019 Sep 5;20(18):4364. doi: 10.3390/ijms20184364. Int J Mol Sci. 2019. PMID: 31491973 Free PMC article. Review.