Mediators of human mast cells and human mast cell subsets

Ann Allergy. 1987 Apr;58(4):226-35.

Abstract

Although a great deal has been learned about the mediators produced by mast cells, the ultimate biologic function(s) of mast cell remains a mystery. Histamine, LTC4, PAF, and possibly tryptase (C3a generation) all enhance vasopermeability. Mediators with anticoagulant activities such as heparin and tryptase (fibrinogenolysis) and antithrombotic activity, PGD2, would appear to facilitate dispersion in tissues of the plasma ultrafiltrate brought there by the subgroup of mediators that enhance vasopermeability. In contrast, PAF causes platelet aggregation and chymase may cause arteriolar vasoconstriction (decreasing the volume of plasma reaching venules) by generation of angiotensin II. Assessment of any differential production of mediators by different types of mast cells will be of obvious importance in sorting out the physiologic responses to mast cell activation as well as the pathophysiology of allergic reactions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Arachidonic Acid
  • Arachidonic Acids / immunology
  • Arachidonic Acids / metabolism
  • Histamine / immunology
  • Histamine / metabolism
  • Humans
  • Mast Cells / classification
  • Mast Cells / immunology*
  • Mast Cells / metabolism
  • Peptide Hydrolases / immunology
  • Peptide Hydrolases / metabolism
  • Proteoglycans / immunology
  • Proteoglycans / metabolism
  • Receptors, Histamine / immunology
  • Receptors, Histamine / metabolism

Substances

  • Arachidonic Acids
  • Proteoglycans
  • Receptors, Histamine
  • Arachidonic Acid
  • Histamine
  • Peptide Hydrolases