Bridging the gap: Mechanisms of plasticity and repair after pediatric TBI

Naomi S Sta Maria; Saman Sargolzaei; Mayumi L Prins; Emily L Dennis; Robert F Asarnow; David A Hovda; Neil G Harris; Christopher C Giza

doi:10.1016/j.expneurol.2019.04.016

Bridging the gap: Mechanisms of plasticity and repair after pediatric TBI

Exp Neurol. 2019 Aug:318:78-91. doi: 10.1016/j.expneurol.2019.04.016. Epub 2019 May 2.

Authors

Naomi S Sta Maria¹, Saman Sargolzaei², Mayumi L Prins³, Emily L Dennis⁴, Robert F Asarnow⁵, David A Hovda⁶, Neil G Harris⁷, Christopher C Giza⁸

Affiliations

¹ Department of Physiology and Neuroscience, Zilkha Neurogenetic Institute, University of Southern California, 1501 San Pablo Street, ZNI115, Los Angeles, CA 90033, United States of America. Electronic address: nstamari@usc.edu.
² UCLA Brain Injury Research Center, Department of Neurosurgery, University of California at Los Angeles, Box 956901, 300 Stein Plaza, Ste 562, 5th Floor, Los Angeles, CA 90095-6901, United States of America. Electronic address: ssargolzaei@mednet.ucla.edu.
³ UCLA Brain Injury Research Center, Department of Neurosurgery, University of California at Los Angeles, Box 956901, 300 Stein Plaza, Ste 562, 5th Floor, Los Angeles, CA 90095-6901, United States of America; Steve Tisch BrainSPORT Program, University of California at Los Angeles, Los Angeles, CA, United States of America. Electronic address: mprins@mednet.ucla.edu.
⁴ Brigham and Women's Hospital/Harvard University and Department of Psychology, Stanford University, 1249 Boylston Street, Boston, MA 02215, United States of America. Electronic address: edennis@bwh.harvard.edu.
⁵ Department of Psychiatry and Biobehavioral Sciences, University of California at Los Angeles, Box 951759, 760 Westwood Plaza, 48-240C Semel Institute, Los Angeles, CA 90095-1759, United States of America. Electronic address: rasarnow@mednet.ucla.edu.
⁶ UCLA Brain Injury Research Center, Department of Neurosurgery, University of California at Los Angeles, Box 956901, 300 Stein Plaza, Ste 562, 5th Floor, Los Angeles, CA 90095-6901, United States of America; Department of Medical and Molecular Pharmacology, University of California at Los Angeles, Box 956901, 300 Stein Plaza, Ste 562 & Semel 18-228A, Los Angeles, CA 90095-6901, United States of America. Electronic address: dhovda@mednet.ucla.edu.
⁷ UCLA Brain Injury Research Center, Department of Neurosurgery, University of California at Los Angeles, Box 956901, 300 Stein Plaza, Ste 562, 5th Floor, Los Angeles, CA 90095-6901, United States of America; Intellectual Development and Disabilities Research Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, United States of America. Electronic address: ngharris@ucla.edu.
⁸ UCLA Brain Injury Research Center, Department of Neurosurgery, University of California at Los Angeles, Box 956901, 300 Stein Plaza, Ste 562, 5th Floor, Los Angeles, CA 90095-6901, United States of America; Steve Tisch BrainSPORT Program, University of California at Los Angeles, Los Angeles, CA, United States of America; Division of Pediatric Neurology, Mattel Children's Hospital - UCLA, Los Angeles, CA, United States of America. Electronic address: cgiza@mednet.ucla.edu.

Abstract

Traumatic brain injury is the leading cause of death and disability in the United States, and may be associated with long lasting impairments into adulthood. The multitude of ongoing neurobiological processes that occur during brain maturation confer both considerable vulnerability to TBI but may also provide adaptability and potential for recovery. This review will examine and synthesize our current understanding of developmental neurobiology in the context of pediatric TBI. Delineating this biology will facilitate more targeted initial care, mechanism-based therapeutic interventions and better long-term prognostication and follow-up.

Keywords: Development; Pediatric TBI; Plasticity; Traumatic brain injury.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Brain Injuries, Traumatic / physiopathology*
Child
Child, Preschool
Humans
Infant
Infant, Newborn
Nerve Regeneration / physiology*
Neuronal Plasticity / physiology*
Recovery of Function / physiology*

Abstract

Publication types

MeSH terms

Grants and funding