Epidermal growth factor actions on arachidonic acid metabolism in human amnion cells

Biochim Biophys Acta. 1987 Apr 22;928(2):240-2. doi: 10.1016/0167-4889(87)90127-3.

Abstract

Epidermal growth factor (EGF) from human and murine sources increased prostaglandin E2 production by human amnion cells. An anti-EGF receptor monoclonal antibody abolished this stimulatory action of EGF and reduced the basal rate of amnion prostaglandin E2 biosynthesis. The rates of formation of arachidonate lipoxygenase products were also enhanced by EGF.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amnion / drug effects*
  • Amnion / metabolism
  • Arachidonate Lipoxygenases / metabolism
  • Arachidonic Acid
  • Arachidonic Acids / metabolism*
  • Cells, Cultured
  • Dinoprostone
  • Epidermal Growth Factor / pharmacology*
  • ErbB Receptors / metabolism
  • Humans
  • Prostaglandins E / biosynthesis

Substances

  • Arachidonic Acids
  • Prostaglandins E
  • Arachidonic Acid
  • Epidermal Growth Factor
  • Arachidonate Lipoxygenases
  • ErbB Receptors
  • Dinoprostone