Low antimüllerian hormone (AMH) is associated with decreased live birth after in vitro fertilization when follicle-stimulating hormone and AMH are discordant

Fertil Steril. 2019 Jul;112(1):73-81.e1. doi: 10.1016/j.fertnstert.2019.03.022. Epub 2019 May 2.


Objective: To evaluate which factor, AMH or FSH, was superior in predicting live birth after assisted reproductive technologies (ART) when the tests are discordant, using data from the Society for Assisted Reproductive Technology Clinical Outcomes Reporting System database.

Design: Retrospective cohort.

Setting: Clinic-based data.

Patient(s): The study population included 44,696 fresh embryo transfer cycles using autologous oocytes.

Intervention(s): None.

Main outcome measure(s): Live birth (≥22 wk gestation and ≥300 g birth weight).

Result(s): Live birth rate per started cycle was lower in patients with low AMH and normal FSH than in patients with normal AMH and elevated FSH (26% vs. 39%). A multivariate analysis was performed on patients with normal FSH and low AMH, and the following factors were independently associated with live birth: AMH, age >40 years, body mass index >30 kg/m2, race African-American or Asian, IVF clinic region West, uterine factor infertility diagnosis, agonist suppression, and FSH dosage. IVF cycle cancellation rate was higher in patients with low AMH and normal FSH (30%).

Conclusion(s): AMH is a superior predictor of live birth in patients undergoing IVF when FSH and AMH values are discordant. Lower AMH is independently associated with lower live birth and higher IVF cycle cancellation rates than elevated FSH in patients with discordant values.

Keywords: AMH; FSH; live birth.

MeSH terms

  • Adolescent
  • Adult
  • Anti-Mullerian Hormone / blood*
  • Biomarkers / blood
  • Down-Regulation
  • Female
  • Fertility
  • Fertilization in Vitro / adverse effects*
  • Follicle Stimulating Hormone, Human / blood*
  • Humans
  • Infertility / blood
  • Infertility / physiopathology
  • Infertility / therapy*
  • Live Birth
  • Middle Aged
  • Predictive Value of Tests
  • Pregnancy
  • Pregnancy Rate
  • Retrospective Studies
  • Risk Factors
  • Treatment Outcome
  • Young Adult


  • Biomarkers
  • Follicle Stimulating Hormone, Human
  • Anti-Mullerian Hormone