Infant Pneumococcal Carriage During Influenza, RSV, and hMPV Respiratory Illness Within a Maternal Influenza Immunization Trial

J Infect Dis. 2019 Aug 9;220(6):956-960. doi: 10.1093/infdis/jiz212.

Abstract

In this post-hoc analysis of midnasal pneumococcal carriage in a community-based, randomized prenatal influenza vaccination trial in Nepal with weekly infant respiratory illness surveillance, 457 of 605 (75.5%) infants with influenza, respiratory syncytial virus (RSV), or human metapneumovirus (hMPV) illness had pneumococcus detected. Pneumococcal carriage did not impact rates of lower respiratory tract disease for these 3 viruses. Influenza-positive infants born to mothers given influenza vaccine had lower pneumococcal carriage rates compared to influenza-positive infants born to mothers receiving placebo (58.1% versus 71.6%, P = 0.03). Maternal influenza immunization may impact infant acquisition of pneumococcus during influenza infection. Clinical Trials Registration. NCT01034254.

Keywords: RSV; hMPV; influenza; maternal immunization; pneumococcus; vaccine.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Influenza Vaccines*
  • Influenza, Human / epidemiology*
  • Influenza, Human / prevention & control
  • Metapneumovirus
  • Mothers
  • Nepal
  • Paramyxoviridae Infections / epidemiology*
  • Paramyxoviridae Infections / prevention & control
  • Pneumococcal Infections / epidemiology*
  • Pneumococcal Infections / prevention & control
  • Pregnancy
  • Pregnancy Complications, Infectious / prevention & control
  • Respiratory Syncytial Virus Infections / epidemiology*
  • Respiratory Syncytial Virus Infections / prevention & control
  • Respiratory Syncytial Virus, Human
  • Respiratory Tract Infections / epidemiology
  • Respiratory Tract Infections / prevention & control
  • Respiratory Tract Infections / virology
  • Streptococcus pneumoniae
  • Vaccination*

Substances

  • Influenza Vaccines

Associated data

  • ClinicalTrials.gov/NCT01034254