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The Roles of Post-translational Modifications on α-Synuclein in the Pathogenesis of Parkinson's Diseases

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Review

The Roles of Post-translational Modifications on α-Synuclein in the Pathogenesis of Parkinson's Diseases

Jiaming Zhang et al. Front Neurosci.

Abstract

Parkinson's disease is the second most common neurodegenerative disorder. Although the pathogenesis of Parkinson's disease is not entirely clear, the aberrant aggregation of α-synuclein has long been considered as an important risk factor. Elucidating the mechanisms that influence the aggregation of α-synuclein is essential for developing an effective diagnostic, preventative and therapeutic strategy to treat this devastating disease. The aggregation of α-synuclein is influenced by several post-translational modifications. Here, we summarized the major post-translational modifications (phosphorylation, ubiquitination, truncation, nitration, O-GlcNAcylation) of α-synuclein and the effect of these modifications on α-synuclein aggregation, which may provide potential targets for future therapeutics.

Keywords: Parkinson’s disease; aggregation; post-translational modifications; toxicity; α-synuclein.

Figures

FIGURE 1
FIGURE 1
Major post-translational modifications (PTMs) on various amino acids of α-synuclein.

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