The effects of "yusho" type PCB on triglyceride lipase and fatty acid composition

Environ Res. 1987 Apr;42(2):500-8. doi: 10.1016/s0013-9351(87)80217-7.

Abstract

Yusho type polychlorinated biphenyl (Y-PCB) was prepared in order to study lipid disorder of the PCB poisoning "yusho." Y-PCB caused hypertriglyceridemia and hypercholesterolemia in the rat. Triglyceride lipase (TGL) activities in liver and postheparin serum were suppressed by Y-PCB administration, whereas it was not suppressed in fat. In in vitro experiments, Y-PCB did not suppress TGL in either liver or fat. Although Y-PCB increased fatty acids in the liver 2.5-fold, the relative proportion of fatty acids composition was not changed so remarkably as that in absolute concentrations. These findings suggested that liver is the target of Y-PCB -mediated alteration of lipid metabolism.

MeSH terms

  • Adipose Tissue / analysis
  • Animals
  • Body Weight / drug effects
  • Fatty Acids / analysis*
  • Lipase / analysis*
  • Liver / analysis
  • Liver / drug effects
  • Male
  • Polychlorinated Biphenyls / toxicity*
  • Rats
  • Rats, Inbred Strains

Substances

  • Fatty Acids
  • Polychlorinated Biphenyls
  • Lipase