IL-28B genetic variation, gender, age, jaundice, hepatitis C virus genotype, and hepatitis B virus and HIV co-infection in spontaneous clearance of hepatitis C virus

Turk J Gastroenterol. 2019 May;30(5):436-444. doi: 10.5152/tjg.2019.18328.


Background/aims: Spontaneous viral clearance observed in some patients is one of the variants of the hepatitis C virus (HCV) infection natural history. We aimed to look at the complexity of factors affecting the spontaneous clearance of HCV (SC HCV).

Materials and methods: A total of 357 anti-HCV positive patients (309 with chronic hepatitis C and 48 patients with SC HCV) were included into the study. We studied the effects of the interleukin-28B (IL-28B) gene polymorphism, gender, age, the routes of virus transmission, past hepatitis C with jaundice, HCV genotype, and hepatitis B virus (HBV) and HIV co-infection on the outcome of HCV infection.

Results: Based on the study results, the SC HCV was found in 48 individuals (13.4%). The most significant positive factors affecting the SC HCV included IL-28B single nucleotide polymorphism (SNP) rs12979860 (CC) and SNP rs8099917 (TT) (OR 4.03, p<0.001) and (OR 3.14, p<0.002), female gender (OR 2.72, p<0.001), young age (OR 2.30, p<0.008), and past history of jaundice (OR 5.12, p<0.001). The markers of a past HBV infection were found significantly more often in SC.

Conclusion: Positive predictors of the SC HCV include favorable IL-28B genotype, female gender, young age, a history of jaundice, markers of a past HBV infection, the absence of HIV infection, but not the viral genotype.

MeSH terms

  • Adult
  • Age Factors
  • Coinfection / genetics
  • Coinfection / virology
  • Female
  • Genotype
  • HIV
  • HIV Infections / genetics*
  • HIV Infections / virology
  • Hepacivirus / genetics*
  • Hepatitis B / genetics*
  • Hepatitis B / virology
  • Hepatitis B virus
  • Hepatitis C, Chronic / genetics*
  • Hepatitis C, Chronic / virology
  • Humans
  • Interferons / genetics*
  • Jaundice / genetics
  • Jaundice / virology
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide
  • Remission, Spontaneous
  • Sex Factors
  • Young Adult


  • IFNL3 protein, human
  • Interferons