RNA-sequencing data highlighting the time-of-day-dependent transcriptome of the central circadian pacemaker in Sox2-deficient mice

Arthur H Cheng; Pascale Bouchard-Cannon; Rob W Ness; Hai-Ying Mary Cheng

doi:10.1016/j.dib.2019.103909

RNA-sequencing data highlighting the time-of-day-dependent transcriptome of the central circadian pacemaker in Sox2-deficient mice

Data Brief. 2019 Apr 8:24:103909. doi: 10.1016/j.dib.2019.103909. eCollection 2019 Jun.

Authors

Arthur H Cheng^{1

2}, Pascale Bouchard-Cannon^{1

2}, Rob W Ness^{1

3}, Hai-Ying Mary Cheng^{1

2}

Affiliations

¹ Department of Biology, University of Toronto Mississauga, Mississauga, ON, L5L 1C6, Canada.
² Department of Cell & Systems Biology, University of Toronto, Toronto, ON, M5S 3G5, Canada.
³ Department of Ecology & Evolutionary Biology, University of Toronto, ON, M5S 3B2, Canada.

Abstract

SOX2 is a stem cell-associated pluripotency transcription factor whose role in neuronal populations is undefined. Here we present the RNA-sequencing based transcriptome profiles of control (Sox2 ^fl/fl ) and SOX2 conditional knock-out (Vgat-cre;Sox2 ^fl/fl ) mice at four time points in one 24-h circadian cycle. The raw sequencing data were deposited to ArrayExpress database at EMBL-EBI (https://www.ebi.ac.uk/arrayexpress) under the accession number E-MTAB-7496. Results of rhythmicity analysis, differential expression analysis, network prediction, and potential target identification stemming from the RNA-sequencing dataset are also given in this article. The interpretation and discussion of these data can be found in the related research article entitled "SOX2-dependent transcription in clock neurons promotes the robustness of the central circadian pacemaker." Cheng et al. 2019.

Keywords: Circadian rhythms; Mice; SOX2; Suprachiasmatic nucleus; Transcriptomics.