ALK7 Erects a Suppressive Barrier to Tumor Progression and Metastasis

Xiaoyi Li; Andrea Ventura

doi:10.1016/j.devcel.2019.04.025

ALK7 Erects a Suppressive Barrier to Tumor Progression and Metastasis

Dev Cell. 2019 May 6;49(3):304-305. doi: 10.1016/j.devcel.2019.04.025.

Authors

Xiaoyi Li¹, Andrea Ventura²

Affiliations

¹ Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Gerstner Sloan Kettering Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
² Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address: venturaa@mskcc.org.

PMID: 31063746
DOI: 10.1016/j.devcel.2019.04.025

Abstract

Overcoming intrinsic and extrinsic tumor-suppressive barriers is an essential feature of tumor progression. In this issue of Developmental Cell, Michael et al. (2019) use the RIP-Tag mouse model to show that pro-apoptotic signals mediated by the Activin B-ALK7 axis suppress ectopic proliferation and metastasis during pancreatic neuroendocrine cancer development.

Publication types

Comment

MeSH terms

Activin Receptors, Type I*
Animals
Carcinogenesis
Cell Transformation, Neoplastic
Mice
Neoplasms*
Signal Transduction

Substances

Activin Receptors, Type I

Grants and funding

R01 CA149707/CA/NCI NIH HHS/United States