EMT and Cancer: More Than Meets the Eye

Rik Derynck; Robert A Weinberg

doi:10.1016/j.devcel.2019.04.026

EMT and Cancer: More Than Meets the Eye

Dev Cell. 2019 May 6;49(3):313-316. doi: 10.1016/j.devcel.2019.04.026.

Authors

Rik Derynck¹, Robert A Weinberg²

Affiliations

¹ Department of Cell and Tissue Biology, and Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California at San Francisco, San Francisco, CA 94143, USA. Electronic address: rik.derynck@ucsf.edu.
² Whitehead Institute for Biomedical Research, MIT Ludwig Center for Molecular Oncology, and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA. Electronic address: weinberg@wi.mit.edu.

Abstract

Epithelial cells acquire mesenchymal characteristics during development, wound healing and inflammation, and in cancer and fibrosis. With increasing appreciation of different roles of epithelial-mesenchymal transition (EMT), we address the question of how to define and recognize EMT processes and discuss their properties in cancer progression.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cell Differentiation / physiology
Epithelial Cells / metabolism
Epithelial Cells / physiology
Epithelial-Mesenchymal Transition / physiology*
Humans
Neoplasms / metabolism*
Signal Transduction
Wound Healing / physiology

Abstract

Publication types

MeSH terms

Grants and funding