The First Hormone: Adrenaline

Trends Endocrinol Metab. 2019 Jun;30(6):331-334. doi: 10.1016/j.tem.2019.03.005. Epub 2019 May 4.


It is not often that three misconceptions are associated with one molecule for more than a century. This is the case with adrenaline. The aim here is to clarify that adrenaline was the first hormone, with the discovery of its activity and chemical purification being prior to secretin. Adrenaline is the correct name given by Jōkichi Takamine, epinephrine being its inactive benzoyl derivative.

MeSH terms

  • Animals
  • Epinephrine / isolation & purification
  • Epinephrine / metabolism*
  • Humans
  • Secretin / metabolism


  • Secretin
  • Epinephrine