Asymmetric Septal Hypertrophy in Appropriate for Gestational Age Infants Born to Diabetic Mothers

Indian Pediatr. 2019 Apr 15;56(4):314-316.


Objective: To compare the frequency of asymmetric septal hypertrophy in appropriate for gestational age infants born to diabetic mothers with those born to non-diabetic mothers.

Methods: We compared 38 full term infants born to diabetic mothers with 85 full term infants of non-diabetic mothers. 2-D echocardiography was obtained in the first 24 hours after birth.

Results: Asymmetric septal hypertrophy was only present in infants born to diabetic mothers (50% vs. 0%; P<0.001). Intraventricular septum thickness and intraventricular septum/posterior wall of the left ventricle ratio was also significantly higher in the first group (P<0.001). We found no correlation between motherĀ“s glycated hemoglobin levels and intraventricular septum thickness in newborns.

Conclusion: Asymmetric septal hypertrophy is a common finding in infants born to diabetic mothers, even if they are appropriate for gestational age.

MeSH terms

  • Diabetes Mellitus / epidemiology
  • Echocardiography
  • Female
  • Gestational Age*
  • Glycated Hemoglobin / analysis
  • Heart Septal Defects* / diagnostic imaging
  • Heart Septal Defects* / epidemiology
  • Heart Septal Defects* / pathology
  • Humans
  • Hypertrophy
  • Infant, Newborn
  • Male
  • Mothers / statistics & numerical data
  • Pregnancy
  • Pregnancy in Diabetics / epidemiology*


  • Glycated Hemoglobin A