New Insights into the Regulation of Leptin Gene Expression

Heike Münzberg; Steven B Heymsfield

doi:10.1016/j.cmet.2019.04.005

New Insights into the Regulation of Leptin Gene Expression

Cell Metab. 2019 May 7;29(5):1013-1014. doi: 10.1016/j.cmet.2019.04.005.

Authors

Heike Münzberg¹, Steven B Heymsfield²

Affiliations

¹ Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA. Electronic address: heike.munzberg@pbrc.edu.
² Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA.

Abstract

Leptin is a key hormone in the homeostatic regulation of body weight. While past research focused mainly on overall leptin actions, a recent study by Dallner et al. (2019) takes a fresh look at the regulatory elements of the leptin gene locus, providing new insights into processes that modulate leptin levels.

Publication types

Comment

MeSH terms

Body Weight
Gene Expression
Humans
Leptin / genetics*
Obesity
RNA, Long Noncoding*

Substances

Leptin
RNA, Long Noncoding

Grants and funding

R01 DK092587/DK/NIDDK NIH HHS/United States