Behaviour modification by in vitro mutagenesis of a variable region within the period gene of Drosophila

Nature. 1987 Apr 23-29;326(6115):765-9. doi: 10.1038/326765a0.


The period gene of Drosophila melanogaster, implicated in the control of both the circadian and male courtship song rhythms, is found to be polymorphic. Alleles differ in the length of a region of the gene encoding a series of threonine-glycine repeat units. The phenotypes of transformed fruit flies, in which the only functional period gene lacks the entire perfect threonine-glycine repeat region, show that the effects of the period gene on the circadian and male courtship song rhythms can be dissociated.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alleles
  • Amino Acid Sequence
  • Animals
  • Circadian Rhythm
  • Drosophila melanogaster / genetics*
  • Drosophila melanogaster / physiology
  • In Vitro Techniques
  • Mutation*
  • Phenotype
  • Sexual Behavior, Animal*
  • Vocalization, Animal