IL2RB maintains immune harmony

J Exp Med. 2019 Jun 3;216(6):1231-1233. doi: 10.1084/jem.20190546. Epub 2019 May 8.

Abstract

How the IL-2 receptor β-chain specifically shapes immunity has remained enigmatic. In this issue of JEM, Zhang et al. (https://doi.org/10.1084/jem.20182304) and Fernandez et al. (https://doi.org/10.1084/jem.20182015) independently report the first observations of autosomal recessive mutations in IL2RB, revealing a requirement for IL2RB in immunity and peripheral immune tolerance.

Publication types

  • Comment

MeSH terms

  • Humans
  • Killer Cells, Natural*
  • Mutation