Involvement of increased p53 expression in the decrease of mitochondrial DNA copy number and increase of SUVmax of FDG-PET scan in esophageal squamous cell carcinoma

Chen-Sung Lin; Yu-Yi Huang; Siao-Cian Pan; Chih-Tao Cheng; Chia-Chuan Liu; Chih-Hsun Shih; Hsiang-Ling Ho; Yi-Chen Yeh; Teh-Ying Chou; Ming-Yuan Lee; Yau-Huei Wei

doi:10.1016/j.mito.2019.05.001

Involvement of increased p53 expression in the decrease of mitochondrial DNA copy number and increase of SUV_max of FDG-PET scan in esophageal squamous cell carcinoma

Mitochondrion. 2019 Jul:47:54-63. doi: 10.1016/j.mito.2019.05.001. Epub 2019 May 6.

Authors

Chen-Sung Lin¹, Yu-Yi Huang², Siao-Cian Pan³, Chih-Tao Cheng⁴, Chia-Chuan Liu⁵, Chih-Hsun Shih⁵, Hsiang-Ling Ho⁶, Yi-Chen Yeh⁷, Teh-Ying Chou⁷, Ming-Yuan Lee⁸, Yau-Huei Wei⁹

Affiliations

¹ Center for General Education, Kainan University, Taoyuan City, Taiwan; School of Life Science, National Taiwan Normal University, Taipei, Taiwan; Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan; Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan; Division of Thoracic Surgery, Taipei Hospital, Ministry of Health and Welfare, New Taipei City, Taiwan; Division of Thoracic Surgery, Koo-Foundation Sun Yat-sen Cancer Center, Taipei, Taiwan.
² Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan; Department of Nuclear Medicine, Koo-Foundation Sun Yat-sen Cancer Center, Taipei, Taiwan.
³ Center for Mitochondrial Medicine and Free Radical Research, Changhua Christian Hospital, Changhua City, Taiwan.
⁴ Division of Psychiatry, Koo-Foundation Sun Yat-sen Cancer Center, Taipei, Taiwan.
⁵ Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan; Division of Thoracic Surgery, Koo-Foundation Sun Yat-sen Cancer Center, Taipei, Taiwan.
⁶ Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
⁷ Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan; Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan; Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
⁸ Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan; Department of Pathology, Koo-Foundation Sun Yat-sen Cancer Center, Taipei, Taiwan. Electronic address: md42jj@kfsyscc.org.
⁹ Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan; Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan; Center for Mitochondrial Medicine and Free Radical Research, Changhua Christian Hospital, Changhua City, Taiwan. Electronic address: 181765@cch.org.tw.

PMID: 31071450
DOI: 10.1016/j.mito.2019.05.001

Abstract

We appraised Warburg effect through analysis of mitochondrial DNA (mtDNA) copy number and maximum standard uptake value (SUV_max) of ¹⁸F-fluorodeoxyglucose positron emission tomography (FDG-PET) scan and their alterations in esophageal squamous cell carcinoma (ESCC). Later T-status and longer longitudinal tumor length were associated with lower mtDNA^ESCC copy number (p < .05) but higher SUV_max-ESCC (p < .05), respectively. Lower mtDNA^ESCC copy number correlated with higher SUV_max-ESCC, reciprocally (p < .05). ESCCs expressing mutant p53 protein had lower mtDNA^ESCC copy number (p = .056) but higher SUV_max-ESCC (p = .046). We conclude that mutant p53 protein may be involved in the Warburg effect of ESCC.

Keywords: (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET); Esophageal squamous cell carcinoma (ESCC); Maximum standard uptake value (SUV(max)); Mitochondrial DNA (mtDNA) copy number; Warburg effect; p53.

Publication types

Clinical Trial
Research Support, Non-U.S. Gov't

MeSH terms

Aged
DNA Copy Number Variations*
DNA, Mitochondrial* / genetics
DNA, Mitochondrial* / metabolism
Esophageal Neoplasms* / diagnostic imaging
Esophageal Neoplasms* / genetics
Esophageal Neoplasms* / metabolism
Esophageal Squamous Cell Carcinoma* / diagnostic imaging
Esophageal Squamous Cell Carcinoma* / genetics
Esophageal Squamous Cell Carcinoma* / metabolism
Female
Fluorodeoxyglucose F18 / administration & dosage*
Gene Expression Regulation, Neoplastic*
Humans
Male
Middle Aged
Positron-Emission Tomography*
Tumor Suppressor Protein p53* / biosynthesis
Tumor Suppressor Protein p53* / genetics

Substances

DNA, Mitochondrial
TP53 protein, human
Tumor Suppressor Protein p53
Fluorodeoxyglucose F18