Evaluation of platelet-rich plasma vs intralesional steroid in treatment of alopecia areata

J Cosmet Dermatol. 2019 Oct;18(5):1456-1462. doi: 10.1111/jocd.12858. Epub 2019 May 10.


Background: Alopecia areata (AA) is nonscarring patchy area of hair loss. Platelets rich plasma (PRP) promotes development of new hair follicles. Dermoscopy is a diagnostic tool that helps in evaluation of skin microstructures which are not visible to naked eye.

Aim: To evaluate safety and efficacy of (PRP) vs intralesional corticosteroid (ILCs) in treatment of AA.

Patients and methods: This study was conducted on 80 patients of both sexes who had AA. Patients were classified into Group I treated by ILCs and group II treated by (PRP). Results were assessed by dermoscopic evaluation and by hair re-growth score (RGS) at (baseline), 2, 4, 6, 8, and 12 weeks. Patients were followed up for 6 months.

Results: There was greater hair re-growth after treatment in both groups. In group I, (26) patients (65%) showed improvement >70% compared to 29 patients (72.5%) in group II. There was significant re-growth of pigmented hair and decrease in dystrophic hair (P < 0.001) by dermoscopic evaluation in both groups. The difference between both groups was insignificant (P = 0.57). At follow-up, two (5%) patients in group II had relapse compared to 10 (25%) patients in group I.

Conclusion: Platelets rich plasma is safe and promising therapeutic option in AA.

Keywords: alopecia areata; dermoscopy; intralesional steroids; platelet-rich plasma.