Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 May 10;10.1002/acr.23924.
doi: 10.1002/acr.23924. Online ahead of print.

Birth Outcomes and Disease Activity During Pregnancy in a Prospective Cohort of Women With Psoriatic Arthritis and Ankylosing Spondylitis

Affiliations
Free PMC article

Birth Outcomes and Disease Activity During Pregnancy in a Prospective Cohort of Women With Psoriatic Arthritis and Ankylosing Spondylitis

Chelsey J F Smith et al. Arthritis Care Res (Hoboken). .
Free PMC article

Abstract

Objective: To add to data on adverse birth outcomes accounting for disease activity in women with psoriatic arthritis (PsA) and ankylosing spondylitis (AS).

Methods: Data were analyzed from women enrolled in the Organization of Teratology Information Specialists (OTIS) Autoimmune Disease Project from 2004-2018. Disease activity was measured by the Health Assessment Questionnaire (HAQ) or Routine Assessment of Patient Index Data 3 (RAPID3). Poisson regression was used to estimate adjusted risk ratios (aRR) with 95% Confidence Intervals (CI) for selected adverse pregnancy outcomes.

Results: Compared to healthy controls (n=717), PsA (n = 117) was associated with increased risk for moderate preterm delivery (32-36 weeks' gestation) (aRR 1.81, 95% CI 1.01-3.26), oligohydramnios (aRR 3.79, 95% CI 1.34-10.74), and Caesarean delivery (aRR 1.63, 95% CI 1.26-2.12). Women with AS (n = 129) had an increased risk of delivering infants requiring intensive care (aRR 1.67, 95% CI 1.05-2.67). High 32 week HAQ score was associated with preterm delivery in women with PsA (aRR 3.82, 95% CI 1.51-9.67). In women with AS, high RAPID3 score was associated with Caesarian delivery (aRR 5.82, 95% 1.06-31.78), and 2nd trimester corticosteroid use was associated with preterm delivery (aRR 4.41, 95% CI 1.57-12.41).

Conclusion: Women with PsA and AS have increased risk for selected adverse pregnancy outcomes. Active disease and corticosteroid use may increase the risk for some adverse pregnancy outcomes in women with these conditions. This article is protected by copyright. All rights reserved.

Conflict of interest statement

Disclosures: The authors report no conflicts of interest or financial disclosures.

Conflicts of Interest

The authors do not have any conflicts of interest to declare.

Similar articles

See all similar articles

Cited by 2 articles

LinkOut - more resources

Feedback