Calcific uremic arteriolopathy (calciphylaxis) calls into question the validity of guidelines of diagnosis and treatment

J Dermatolog Treat. 2020 Aug;31(5):545-548. doi: 10.1080/09546634.2019.1618435. Epub 2019 May 31.


Background: Calciphylaxis is associated with end-stage renal failure or kidney transplant, although, cases of non-uremic calciphylaxis have been reported. It is a rare disorder, with high mortality, characterized by vascular calcification within cutaneous vessels; vascular calcification can occur in other organs, besides skin, like heart, lung, or pancreas, which is named visceral calciphylaxis.Objective: The purpose was to review current knowledge regarding diagnosis and therapeutic approach to cutaneous calciphylaxis.Methods: A literature review has been conducted associated to word "calciphylaxis".Results: The diagnosis is based mainly on clinical features and histologic findings. Therapeutic options are still controversial.Conclusions: Cutaneous calciphylaxis is a puzzling disease, with a challenging diagnosis, and a complex treatment, which requires a multidisciplinary team and expertise.

Keywords: Calcific uremic arteriolopathy; calciphylaxis; chronic hemodialysis.

Publication types

  • Review

MeSH terms

  • Calciphylaxis / diagnosis*
  • Calciphylaxis / etiology
  • Calciphylaxis / therapy
  • Calcium / metabolism
  • Guidelines as Topic
  • Humans
  • Hyperbaric Oxygenation
  • Kidney Failure, Chronic / complications
  • Kidney Failure, Chronic / pathology
  • Kidney Transplantation / adverse effects
  • Skin / pathology


  • Calcium