Update on Recurrent Respiratory Papillomatosis

Otolaryngol Clin North Am. 2019 Aug;52(4):669-679. doi: 10.1016/j.otc.2019.03.011. Epub 2019 May 8.


Recurrent respiratory papillomatosis (RRP) remains a challenging disease afflicting children and adults, resulting in an estimated $120 million per year in United States healthcare-related costs, with annual costs per patient approaching $60,000. Although the prevalence of RRP has declined, RRP remains the most common benign laryngeal neoplasm in children. RRP is unique in its high rate of multisite recurrence, its high burden on patient quality of life, and its high associated healthcare costs. This article summarizes current understanding of the natural history and quality of life burden of RRP, and basic science advancements in prevention and treatment.

Keywords: Bevacizumab; HPV vaccine; Human papillomavirus (HPV); Recurrent respiratory papillomas (RRP).

Publication types

  • Review

MeSH terms

  • Adult
  • Bevacizumab / therapeutic use
  • Child
  • Cost of Illness
  • Humans
  • Papillomavirus Infections / economics*
  • Papillomavirus Infections / epidemiology
  • Papillomavirus Infections / prevention & control
  • Papillomavirus Infections / therapy*
  • Papillomavirus Vaccines
  • Quality of Life
  • Respiratory Tract Infections / economics*
  • Respiratory Tract Infections / epidemiology
  • Respiratory Tract Infections / prevention & control
  • Respiratory Tract Infections / therapy*
  • Surgical Procedures, Operative


  • Papillomavirus Vaccines
  • Bevacizumab

Supplementary concepts

  • Recurrent respiratory papillomatosis