Treadmilling Model for Plasticity of the Myelin Sheath

Trends Neurosci. 2019 Jul;42(7):443-447. doi: 10.1016/j.tins.2019.04.002. Epub 2019 May 8.


We propose a mechanism for myelin plasticity that would complement synaptic plasticity by adjusting conduction velocity for optimal spike-time arrival. In the proposed treadmilling model, myelin sheath thickness is a dynamic balance between the rates of new myelin deposited adjacent to the axon and removal of the outermost layer.

Keywords: astrocyte; myelin plasticity; neurofascin155; oligodendrocyte; spike-time dependent plasticity; thrombin.

Publication types

  • Research Support, N.I.H., Intramural

MeSH terms

  • Animals
  • Humans
  • Models, Neurological*
  • Myelin Sheath / physiology*
  • Synaptic Transmission / physiology*