Novel Approaches to Persistent Pain Therapy

Trends Pharmacol Sci. 2019 Jun;40(6):367-377. doi: 10.1016/ Epub 2019 May 8.


Persistent and neuropathic pain affects >15% of the global population. Apart from being an individual burden to the patient, persistent pain causes considerable subsequent costs in global healthcare systems. Despite the efforts of pharmaceutical companies to develop novel analgesics, pharmacological options for the therapy of persistent and/or neuropathic pain are limited. We discuss here novel approaches to persistent pain therapy that are independent of classical target-based drug discovery, focusing on individualized diagnostic technologies, improvement of existing therapies, and expansion of current pharmacological treatments and future techniques that may broaden pharmacological options for the individual treatment of persistent pain in patients.

Keywords: CRISPR; analgesic; iPSC; monoclonal antibody; opioid; pain.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Chronic Pain / therapy
  • Humans
  • Neuralgia / therapy
  • Pain Management / methods*
  • Pain Management / trends
  • Precision Medicine / methods