Assessing measles vaccine failure in Tianjin, China

Vaccine. 2019 May 31;37(25):3251-3254. doi: 10.1016/j.vaccine.2019.05.005. Epub 2019 May 8.


Despite increasing global measles vaccination coverage, progress toward measles elimination has slowed in recent years. In China, children receive a measles-containing vaccine (MCV) at 8 months, 18-24 months, and some urban areas offer a third dose at age 4-6 years. However, substantial measles cases in Tianjin, China, occur among individuals who have received multiple MCV doses. This study describes the vaccination history of measles cases 8 months - 19 years old. Data came from measles cases in Tianjin's reportable disease surveillance system (2009-2013), and from a case control study (2011-2015). Twenty-nine percent of those in the surveillance dataset and 54.4% of those in the case series received at least one dose of MCV. The minimum and median time-to-diagnosis since vaccination revealed an increase in time since vaccination for incremental doses. Considerable measles cases in Tianjin occur in vaccinated children, and further research is needed to understand the reasons for vaccine failure.

Keywords: China; Measles; Measles-containing vaccine; Tianjin; Vaccine effectiveness; Vaccine failure.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Case-Control Studies
  • Child
  • Child, Preschool
  • China
  • Disease Outbreaks / prevention & control
  • Epidemiological Monitoring
  • Female
  • Humans
  • Immunization Schedule
  • Infant
  • Male
  • Measles / diagnosis
  • Measles / prevention & control*
  • Measles Vaccine / administration & dosage*
  • Treatment Failure
  • Vaccination Coverage / statistics & numerical data*
  • Young Adult


  • Measles Vaccine