Angiotensin II is chemotactic for a T-cell subset which can express migration inhibition factor activity in murine schistosomiasis mansoni

Cell Immunol. 1987 Jun;107(1):180-7. doi: 10.1016/0008-8749(87)90278-4.


In murine schistosomiasis mansoni, ova induce a delayed-type hypersensitivity, granulomatous response in which angiotensins are produced. Angiotensin II (AII) elicits a chemotaxis for splenic mononuclear cells derived from these infected animals. The effect of AII upon the migration of a T-lymphocyte subset was defined functionally to further delineate this observation. A chemotaxis chamber was developed that permitted collection of large numbers of viable cells which migrate in response to AII. In a direct migration inhibition factor (MIF) assay, MIF activity was demonstrated with 100-fold fewer chemotactically attracted cells as opposed to whole splenic leukocytes. The MIF activity was eliminated by treatment of the cells with anti-Lyt 1.1 or-Thy 1.2 serum and complement. This observation was particularly interesting since migrated and whole spleen cell populations comprised equal numbers of T cells. Incubation of spleen cells with AII prior to assay did not alter MIF activity. These findings suggest that AII is chemotactic for at least one important T-cell subset relevant to the granulomatous response.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Angiotensin II / physiology*
  • Animals
  • Chemotactic Factors*
  • Chemotaxis, Leukocyte*
  • Female
  • Granuloma / immunology
  • In Vitro Techniques
  • Macrophage Migration-Inhibitory Factors / immunology*
  • Mice
  • Mice, Inbred CBA
  • Schistosomiasis mansoni / immunology*
  • Spleen / cytology
  • T-Lymphocytes / classification
  • T-Lymphocytes / immunology*


  • Chemotactic Factors
  • Macrophage Migration-Inhibitory Factors
  • Angiotensin II