Low-Dose Interleukin-2 Ameliorates Colitis in a Preclinical Humanized Mouse Model

Jeremy A Goettel; Daniel Kotlarz; Rohini Emani; James B Canavan; Liza Konnikova; David Illig; Sandra M Frei; Michael Field; Matthew Kowalik; Kaiyue Peng; Jordan Gringauz; Vanessa Mitsialis; Sarah M Wall; Amy Tsou; Alexandra E Griffith; Ying Huang; Joshua R Friedman; Jennifer E Towne; Scott E Plevy; Aisling O'Hara Hall; Scott B Snapper

doi:10.1016/j.jcmgh.2019.05.001

Low-Dose Interleukin-2 Ameliorates Colitis in a Preclinical Humanized Mouse Model

Cell Mol Gastroenterol Hepatol. 2019;8(2):193-195. doi: 10.1016/j.jcmgh.2019.05.001. Epub 2019 May 9.

Authors

Jeremy A Goettel¹, Daniel Kotlarz², Rohini Emani², James B Canavan³, Liza Konnikova⁴, David Illig⁵, Sandra M Frei², Michael Field⁵, Matthew Kowalik², Kaiyue Peng⁶, Jordan Gringauz⁵, Vanessa Mitsialis³, Sarah M Wall⁵, Amy Tsou², Alexandra E Griffith⁵, Ying Huang⁷, Joshua R Friedman⁸, Jennifer E Towne⁹, Scott E Plevy⁸, Aisling O'Hara Hall⁸, Scott B Snapper¹⁰

Affiliations

¹ Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, Massachusetts; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts. Electronic address: jeremy.goettel@vumc.org.
² Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, Massachusetts; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.
³ Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, Massachusetts; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts; Division of Gastroenterology, Brigham and Women's Hospital, Boston, Massachusetts.
⁴ Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, Massachusetts; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts; Department of Pediatric and Newborn Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
⁵ Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, Massachusetts.
⁶ Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, Massachusetts; Department of Gastroenterology, Children's Hospital of Fudan University, Shanghai, China.
⁷ Department of Gastroenterology, Children's Hospital of Fudan University, Shanghai, China.
⁸ Janssen Research & Development, Spring House, Pennsylvania.
⁹ Janssen Research & Development, San Diego, California.
¹⁰ Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, Massachusetts; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts; Division of Gastroenterology, Brigham and Women's Hospital, Boston, Massachusetts. Electronic address: scott.snapper@childrens.harvard.edu.

No abstract available

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Colitis / drug therapy*
Disease Models, Animal*
Interleukin-2 / therapeutic use*
Mice

Substances

Interleukin-2

Publication types

MeSH terms

Substances

Grants and funding