PA-II, the L-fucose and D-mannose binding lectin of Pseudomonas aeruginosa stimulates human peripheral lymphocytes and murine splenocytes

FEBS Lett. 1987 May 25;216(1):62-6. doi: 10.1016/0014-5793(87)80757-3.


Pseudomonas aeruginosa lectin PA-II agglutinates human peripheral lymphocytes and stimulates mitogenesis (predominantly in T cells), like the plant lectins PHA and Con A. Murine splenocytes are also agglutinated and stimulated by PA-II as by Con A. Sialidase treatment of the human and murine cells enhances their agglutination and augments the stimulation of human lymphocytes at low PA-II concentrations. The PA-II agglutinating and mitogenic effects are specifically inhibited by L-fucose. The bacterial source and the specificity of PA-II for L-fucose are both rare features among the hitherto described mitogenic lectins. However, since this lectin also binds mannose, a mannose-bearing receptor might be involved in its mitogenicity.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adhesins, Bacterial*
  • Animals
  • Bacterial Proteins / antagonists & inhibitors
  • Bacterial Proteins / pharmacology*
  • Concanavalin A / pharmacology
  • Fucose / pharmacology
  • Humans
  • Lectins*
  • Lymphocyte Activation / drug effects*
  • Lymphocytes / drug effects*
  • Mannose / metabolism
  • Mice
  • Neuraminidase / pharmacology
  • Phytohemagglutinins / pharmacology
  • Pseudomonas aeruginosa
  • Spleen / cytology


  • Adhesins, Bacterial
  • Bacterial Proteins
  • Lectins
  • Phytohemagglutinins
  • adhesin, Pseudomonas
  • Concanavalin A
  • Fucose
  • Neuraminidase
  • Mannose