Effects of boric acid-linked ampicillin on the rat intra-abdominal sepsis model

Pak J Pharm Sci. 2019 Mar;32(2):477-481.


The aim of this study was to determine efficiency of a new molecule that was obtained by linking boric acid with ampicillin in treating intra-abdominal infection.Following intraperitoneal E. coli injection totwenty-one female Wistar albino rats, group 1 was administered boron-linked ampicillin, group 2 was administered only ampicillin and group 3 was injected intraperitoneally with physiological serum. IL-6, and a white blood cell analysis was performed from the blood before and on the seventh day of treatment.No statistically significant difference in blood WBC levels after treatment was found among the groups. There was no statistically significant difference in the IL-6 values of group 2 and group 3 before and after the treatment (p=0.195 and 0.193, respectively); however, the reduction in the serum IL-6 values of group 1 was statistically significant (p=0.003).Boric acid-linked ampicillin is a more effective intra-abdominal infection treatment compared with ampicillin alone.

MeSH terms

  • Abdomen
  • Ampicillin / chemistry
  • Ampicillin / pharmacology*
  • Animals
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology*
  • Boric Acids / chemistry
  • Boric Acids / pharmacology*
  • Disease Models, Animal
  • Female
  • Interleukin-6 / blood
  • Rats, Wistar
  • Sepsis / blood
  • Sepsis / drug therapy*
  • Sepsis / mortality


  • Anti-Bacterial Agents
  • Boric Acids
  • Il6 protein, rat
  • Interleukin-6
  • Ampicillin
  • boric acid