Vulvar Intraepithelial Neoplasia

Excerpt

Vulvar intraepithelial neoplasia (VIN) is a noninvasive squamous lesion and precursor of squamous cell carcinoma (SCC) of the vulva. Because there is no screening test for VIN, careful examination and biopsy of its various clinical lesions are essential. VIN lesions can be raised, flat, white, gray, or pigmented; diagnosis is made clinically and confirmed with a biopsy.

In 2015, the International Society for the Study of Vulvovaginal Disease (ISSVD) proposed this classification for vulvar squamous intraepithelial lesions (SILs):

1. Low-grade SIL (LSIL) of the vulva

   1. Vulvar LSIL, flat condyloma, or human papillomavirus (HPV) effect

   2. Previously referred to as VIN 1

2. High-grade SIL (HSIL) of the vulva

   1. Vulvar HSIL, VIN usual type (uVIN)

   2. Previously referred to as VIN 2 and VIN 3

3. Differentiated VIN (dVIN)

   1. Previously referred to as VIN simplex type