IgA nephropathy associated with erythrodermic psoriasis: A case report

Medicine (Baltimore). 2019 May;98(19):e15433. doi: 10.1097/MD.0000000000015433.


Rationale: Cases about IgAN associated with EP are rare and the pathogenesis is poorly understood. We reported a 74-year-old Chinese male who suffered the IgAN and EP at the same time and explored a possible pathophysiologic link and points toward the possible pathogenesis.

Patient concerns: The patient complained deteriorating symptoms (erythrodermia, skin pruritus, and pain) of psoriasis and obvious pitting edema on his legs.

Diagnosis: The patient was diagnosed as IgAN and EP concurrently according to medical history, physical examination, laboratory test, and pathology.

Interventions: Intravenous dexamethasone (5 mg/day) and oral ciclosporin (200 mg twice a day).

Outcomes: The patient's symptoms of psoriasis and IgA nephropathy improved obviously after 11-day treatment and discharged from the hospital.

Lessons: IgAN should be considered when the patient is diagnosed as EP. The combination of dexamethasone and ciclosporin may be effective option for patients with IgAN and EP concurrently.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Diagnosis, Differential
  • Glomerulonephritis, IGA / complications*
  • Glomerulonephritis, IGA / diagnosis*
  • Glomerulonephritis, IGA / drug therapy
  • Glomerulonephritis, IGA / immunology
  • Humans
  • Male
  • Psoriasis / complications*
  • Psoriasis / diagnosis*
  • Psoriasis / drug therapy
  • Psoriasis / immunology
  • Skin / immunology
  • Skin / pathology