Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 98 (19), e15605

The Relationship of CRP and Cognition in Cognitively Normal Older Mexican Americans: A Cross-Sectional Study of the HABLE Cohort

The Relationship of CRP and Cognition in Cognitively Normal Older Mexican Americans: A Cross-Sectional Study of the HABLE Cohort

Raul Vintimilla et al. Medicine (Baltimore).

Abstract

C-reactive protein (CRP) is a biomarker for cardiovascular events and also has been studied as a biomarker for cognitive decline. By the year 2050 the Hispanic population in the United States will reach 106 million, and 65% of those will be of Mexican heritage. The purpose of this study was to evaluate the association between CRP levels and cognitive functioning in a sample of Mexican American older adults. A cross-sectional analysis of data from 328 cognitive normal, Mexican American participants from the community-based Health and Aging Brain Among Latino Elders (HABLE) study were performed. Statistical methods included t-test, chi square, multiple linear regression, and logistic regression modeling. Cognitive performance was measured by the Mini Mental State Examination (MMSE), Logical Memory I and II, Digit Span, FAS, and Animal Naming tests. Age, years of education, gender, diagnostic of hypertension, diabetes, and dyslipidemia were entered in the model as covariates. High CRP levels significantly predicted FAS scores (B = -0.135, P = .01), even after adjusting for covariates. Education (B = 0.30, P < .05), and diagnosis of hypertension (B = -0.12, P = .02) were also independent predictors of FAS scores. Participants with higher CRP levels had greater adjusted odds of poorer performance in the FAS test (OR = 1.75, 95% CI = 1.13-2.72, P = .01) when compared to participants with lower CRP levels. This was also true for participants with hypertension (OR = 2.20, 95% CI = 1.34-3.60, P < .05). Higher CRP levels were not associated with MMSE, logical memory, digit span, and animal naming scores. In conclusion, our study showed a clear association between CRP levels and verbal fluency and executive function in a cognitively normal community-dwelling population of Mexican-Americans.

Conflict of interest statement

Conflicts of interest: The authors have no conflicts of interest to declare.

Similar articles

See all similar articles

Cited by 1 PubMed Central articles

References

    1. Kop WJ, Gottdiener JS, Tangen CM, et al. Inflammation and coagulation factors in persons >65 years of age with symptoms of depression but without evidence of myocardial ischemia. Am J Cardiol 2002;89:419–24. - PubMed
    1. Penninx BW, Kritchevsky SB, Yaffe K, et al. Inflammatory markers and depressed mood in older persons: results from the Health, Aging and Body Composition study. Biol Psychiatry 2003;54:566–72. - PubMed
    1. Siemes C, Visser L, Jan-Willen W, et al. C-reactive protein levels, variation in the C-reactive protein gene, and cancer risk: the Rotterdam Study. J Clin Oncol 2006;24:5216–22. - PubMed
    1. Gunter MJ, Stolzenberg-Solomon R, Cross AJ, et al. A Prospective Study of serum C-reactive protein and colorectal cancer risk in men. Cancer Res 2006;66:2483–7. - PubMed
    1. Guo L, Liu S, Zhang S, et al. C-reactive protein and risk of breast cancer: a systematic review and meta-analysis. Sci Rep 2015;5:10508. - PMC - PubMed

Substances

Feedback