Teaching an Old Drug New Tricks

Milica Momcilovic; David B Shackelford

doi:10.1016/j.ccell.2019.04.008

Teaching an Old Drug New Tricks

Cancer Cell. 2019 May 13;35(5):709-711. doi: 10.1016/j.ccell.2019.04.008.

Authors

Milica Momcilovic¹, David B Shackelford²

Affiliations

¹ Division of Pulmonary and Critical Care Medicine, Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles, CA 90095, USA.
² Division of Pulmonary and Critical Care Medicine, Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at the University of California, Los Angeles, CA 90095, USA. Electronic address: dshackelford@mednet.ucla.edu.

PMID: 31085172
DOI: 10.1016/j.ccell.2019.04.008

Abstract

In this issue of Cancer Cell, Elgendy et al. describe the use of intermittent fasting as a strategy to reduce tumor glucose levels and sensitize otherwise resistant tumor cells to metformin. The authors demonstrate that intermittent fasting before metformin treatment sensitized tumors to metformin and significantly reduced tumor growth.

Publication types

Comment

MeSH terms

Fasting
Glycogen Synthase Kinase 3 beta
Humans
Hypoglycemia*
Metformin*
Myeloid Cell Leukemia Sequence 1 Protein

Substances

Myeloid Cell Leukemia Sequence 1 Protein
Metformin
Glycogen Synthase Kinase 3 beta