Physicochemical characterization of barrier membranes for bone regeneration

Jordi Caballé-Serrano; Antonio Munar-Frau; Luis Delgado; Roman Pérez; Federico Hernández-Alfaro

doi:10.1016/j.jmbbm.2019.04.053

Physicochemical characterization of barrier membranes for bone regeneration

J Mech Behav Biomed Mater. 2019 Sep:97:13-20. doi: 10.1016/j.jmbbm.2019.04.053. Epub 2019 May 4.

Authors

Jordi Caballé-Serrano¹, Antonio Munar-Frau², Luis Delgado³, Roman Pérez³, Federico Hernández-Alfaro²

Affiliations

¹ Department of Oral and Maxillofacial Surgery, School of Dental Medicine, Universitat Internacional de Catalunya, Barcelona, Spain; Department of Oral Surgery and Stomatology, School of Dental Medicine, University of Bern, Switzerland; Robert K. Schenk Laboratory of Oral Histology, School of Dental Medicine, University of Bern, Switzerland. Electronic address: jordicase@uic.es.
² Department of Oral and Maxillofacial Surgery, School of Dental Medicine, Universitat Internacional de Catalunya, Barcelona, Spain.
³ Bioengineering Institute of Technology, Universitat Internacional de Catalunya, Barcelona, Spain.

PMID: 31085456
DOI: 10.1016/j.jmbbm.2019.04.053

Abstract

Barrier membranes are essential biomaterials for guided bone regeneration. Due to different origin and structure of barrier membranes, singular mechanical properties and clinical behaviors can be expected. It is important to understand the physic and chemical properties of barrier membranes to select the needed biomaterial for each clinical situation. To date, no study has evaluated and compared the physicochemical properties of various families of barrier membranes. The aim of this study is to evaluate the physicochemical properties of various barrier membranes. Fifteen membranes of different origin were tested in this study. Membranes were divided into biological or synthetic origin and grouped in natural allogenic collagen, natural xenogenic collagen, cross-linked collagen and synthetic membranes. Physicochemical properties were evaluated in terms of tension, stiffness, absorption ability, pH and wettability. For the tension tests, all membranes showed similar low tension and low stiffness, especially after a 4-min hydration, except for bone laminas that showed a greater stiffness particularly in a dry status. Regarding wettability and hydration of the barrier membranes, porcine origin membranes had greater hydration; wettability was also superior in porcine derived barrier membranes and showed a faster absorption of the drop on the rough surfaces. All membranes had a stable pH, having the synthetic membranes the most stable pH when compared to physiologic. The wide variety of barrier membranes opens a debate in which the practitioner should select the adequate barrier membrane for each clinical situation. Different materials show singular potentials depending on their tissue origin making them suitable for specific clinical indications. More studies regarding adsorption, integration and degradation of barrier membranes are needed to understand their behavior.

Keywords: Barrier membrane; Biomaterial; Collagen membrane; Guided bone regeneration; Oral surgery; Physicochemical.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Biocompatible Materials / chemistry*
Bone Regeneration*
Cattle
Collagen / chemistry*
Guided Tissue Regeneration / instrumentation*
Guided Tissue Regeneration / methods
Hydrogen-Ion Concentration
Image Processing, Computer-Assisted
Materials Testing
Membranes, Artificial
Microscopy, Electron, Scanning
Stress, Mechanical
Swine
Tensile Strength
Wettability

Substances

Biocompatible Materials
Membranes, Artificial
Collagen