The Incidence of Postoperative Seizures Following Treatment of Postinfectious Hydrocephalus in Ugandan Infants: A Post Hoc Comparison of Endoscopic Treatment vs Shunt Placement in a Randomized Controlled Trial

Neurosurgery. 2019 Oct 1;85(4):E714-E721. doi: 10.1093/neuros/nyz122.

Abstract

Background: There are currently no published data directly comparing postoperative seizure incidence following endoscopic third ventriculostomy (ETV), with/without choroid plexus cauterization (CPC), to that for ventriculoperitoneal shunt (VPS) placement.

Objective: To compare postoperative epilepsy incidence for ETV/CPC and VPS in Ugandan infants treated for postinfectious hydrocephalus (PIH).

Methods: We performed an exploratory post hoc analysis of a randomized trial comparing VPS and ETV/CPC in 100 infants (<6 mo old) presenting with PIH. Minimum follow-up was 2 yr. Variables associated with and the incidence of postoperative epilepsy were compared (intention-to-treat) using a bivariate analysis. Time to first seizure was compared using the Kaplan-Meier method, and the relative risk for the 2 treatments was determined using Mantel-Haenszel hazard ratios.

Results: Seizure incidence was not related to age (P = .075), weight (P = .768), sex (P = .151), head circumference (P = .281), time from illness to hydrocephalus onset (P = .973), or hydrocephalus onset to treatment (P = .074). Irritability (P = .027) and vision deficit (P = .04) were preoperative symptoms associated with postoperative seizures. Ten (10%) patients died, and 20 (20%) developed seizures over the follow-up period. Overall seizure incidence was 9.4 per 100 person-years (9.4 and 9.5 for ETV/CPC and VPS, respectively; P = .483), with no significant difference in seizure risk between groups (hazard ratio, 1.02; 95% CI: 0.42, 2.45; P = .966). Mean time to seizure onset was 8.5 mo for ETV/CPC and 11.2 mo for VPS (P = .464). As-treated, per-protocol, and attributable-intervention analyses yielded similar results.

Conclusion: Postoperative seizure incidence following treatment of PIH was 20% within 2 yr, regardless of treatment modality.

Trial registration: ClinicalTrials.gov NCT01936272.

Keywords: ETV/CPC; Epilepsy; Global neurosurgery; Postinfectious hydrocephalus; Seizures; Uganda; VPS; Ventriculoperitoneal shunt.

Publication types

  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural

MeSH terms

  • Female
  • Follow-Up Studies
  • Humans
  • Hydrocephalus / epidemiology*
  • Hydrocephalus / surgery*
  • Incidence
  • Infant
  • Male
  • Neuroendoscopy / adverse effects
  • Neuroendoscopy / trends*
  • Postoperative Complications / diagnosis
  • Postoperative Complications / epidemiology*
  • Seizures / diagnosis
  • Seizures / epidemiology*
  • Treatment Outcome
  • Uganda / epidemiology
  • Ventriculoperitoneal Shunt / adverse effects
  • Ventriculoperitoneal Shunt / trends
  • Ventriculostomy / adverse effects
  • Ventriculostomy / trends*

Associated data

  • ClinicalTrials.gov/NCT01936272