Use of whole-genome sequencing to guide a Clostridioides difficile diagnostic stewardship program

Infect Control Hosp Epidemiol. 2019 Jul;40(7):804-806. doi: 10.1017/ice.2019.124. Epub 2019 May 15.


Whole-genome sequencing (WGS) has yielded new insights into the transmission patterns of healthcare facility-onset Clostridioides difficile infection (HO-CDI). WGS results prompted a focused diagnostic stewardship program, which was associated with a significant and sustained decrease in HO-CDI at large, urban hospital.

MeSH terms

  • Clostridioides difficile / genetics*
  • Clostridioides difficile / isolation & purification*
  • Clostridium Infections / diagnosis*
  • Clostridium Infections / transmission*
  • Cross Infection / diagnosis*
  • Cross Infection / microbiology
  • Cross Infection / transmission
  • Genome, Bacterial
  • Health Facilities
  • Humans
  • Ribotyping
  • Whole Genome Sequencing