Recent waves of controversies surrounding genetic engineering have spilled into popular science in Twitter battles between reputable scientists and their followers. Here, a cautionary perspective on the possible blind spots and risks of CRISPR and related biotechnologies is presented, focusing in particular on the stochastic nature of cellular control processes.
Keywords: CRISPR; biotechnology; gene regulatory networks; genetic editing; noise; nonlinear dynamics; stochasticity.
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A Crispr Future for Gene-Editing Regulation: A Proposal for an Updated Biotechnology Regulatory System in an Era of Human Genomic EditingT Tomlinson. Fordham Law Rev 87 (1), 437-83. PMID 30296034.Recent developments in gene-editing technology have enabled scientists to manipulate the human genome in unprecedented ways. One technology in particular, Clustered Regul …
CRISPR-Cas9/Cas12a Biotechnology and Application in BacteriaR Yao et al. Synth Syst Biotechnol 3 (3), 135-149. PMID 30345399. - ReviewCRISPR-Cas technologies have greatly reshaped the biology field. In this review, we discuss the CRISPR-Cas with a particular focus on the associated technologies and appl …
CRISPR as a Driving Force: The Model T of BiotechnologyC Mariscal et al. Monash Bioeth Rev 34 (2), 101-116. PMID 27619650.The CRISPR system for gene editing can break, repair, and replace targeted sections of DNA. Although CRISPR gene editing has important therapeutic potential, it raises se …
From Precaution to Peril: Public Relations Across Forty Years of Genetic EngineeringAJ Hogan. Endeavour 40 (4), 218-222. PMID 27720215.The Asilomar conference on genetic engineering in 1975 has long been pointed to by scientists as a model for internal regulation and public engagement. In 2015, the organ …
New Variants of CRISPR RNA-guided Genome Editing EnzymesJ Murovec et al. Plant Biotechnol J 15 (8), 917-926. PMID 28371222. - ReviewCRISPR-mediated genome editing using the Streptococcus pyogenes Cas9 enzyme is revolutionizing life science by providing new, precise, facile and high-throughput tools fo …