Role of intestinal microbiota in the formation of non-alcoholic fatty liver disease

Ter Arkh. 2019 Mar 18;91(2):143-148. doi: 10.26442/00403660.2019.02.000051.

Abstract

The article provides an overview of modern views on the role of intestinal microbiota in the formation of non-alcoholic fatty liver disease. The general questions of the pathogenesis of the syndrome of excessive bacterial growth in the intestine, the participation of opportunistic microflora, the deficit of representatives of normal microflora, changes in the species composition of bile acids in the pathogenesis of nonalcoholic fatty liver disease are considered.

Keywords: metabolic syndrome; non-alcoholic fatty liver disease; obesity; syndrome of excessive bacterial growth in the intestine.

Publication types

  • Review

MeSH terms

  • Bacteria
  • Gastrointestinal Microbiome / physiology*
  • Humans
  • Intestines / microbiology*
  • Liver
  • Non-alcoholic Fatty Liver Disease / etiology*
  • Non-alcoholic Fatty Liver Disease / microbiology*