Leksell Radiosurgery for the 3 H Tumors: Hemangiomas, Hemangioblastomas, and Hemangiopericytomas

Prog Neurol Surg. 2019:34:223-231. doi: 10.1159/000493068. Epub 2019 May 16.


Leksell stereotactic radiosurgery has proven to be effective for less common tumors encountered in the brain, including hemangiomas of the orbit or cavernous sinus, recurrent hemangiopericytomas, and both sporadic hemangioblastomas as well as those encountered in the context of von Hippel-Lindau (VHL) disease. While all three tumors are responsive to single-session radiosurgery, hemangiomas and hemangiopericytomas are the most likely to demonstrate tumor regression. Hemangiopericytomas that recur after initial resection can be lower grade or anaplastic and have both higher local as well as distant recurrence risks. Sporadic hemangioblastomas undergo Leksell radiosurgery at the time of recurrence after initial surgery. In the context of VHL, growing or recurrent tumors are treated with tumor control rates exceeding 90%. Tumor control improves with higher dose delivery, typically >15 Gy at the margin. Dose-limiting structures may include the optic apparatus for hemangiomas and brain stem locations for hemangioblastomas.

Publication types

  • Review

MeSH terms

  • Brain Neoplasms / radiotherapy*
  • Brain Neoplasms / surgery
  • Hemangioblastoma / radiotherapy*
  • Hemangioblastoma / surgery
  • Hemangioma / radiotherapy*
  • Hemangioma / surgery
  • Hemangiopericytoma / radiotherapy*
  • Hemangiopericytoma / surgery
  • Humans
  • Neoplasm Recurrence, Local / radiotherapy*
  • Neoplasm Recurrence, Local / surgery
  • Radiosurgery / methods*
  • von Hippel-Lindau Disease / radiotherapy*
  • von Hippel-Lindau Disease / surgery