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, 129, 104469

Microglial Mitophagy Mitigates Neuroinflammation in Alzheimer's Disease

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Microglial Mitophagy Mitigates Neuroinflammation in Alzheimer's Disease

Sofie Lautrup et al. Neurochem Int.

Abstract

In neurons, defective mitophagy results in accumulation of damaged mitochondria, and finally leading to various neurodegenerative diseases, including Alzheimer's disease (AD). However, how mitophagy is defective in AD as well as how defective mitophagy contributes to AD is not fully understood. We give commentary on recent progress of this topic, highlighting the importance of mitophagy not only in neurons, but also in microglia, in forestalling pathology and cognitive decline in different animal models of AD.

Keywords: Ageing; Autophagy; Inflammation; Microglia; Mitophagy; NAD(+).

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