Mitochondrial interaction with the endosomal compartment in endocytosis and mitochondrial transfer

Mitochondrion. 2019 Nov;49:284-288. doi: 10.1016/j.mito.2019.05.003. Epub 2019 May 14.


Mitochondria are essential organelles required for cellular processes ranging from energy production to cellular differentiation. To perform these functions, mitochondria physically and functionally interact with other organelles such as the endoplasmic reticulum (ER) and endosomes. While the role of ER-mitochondria contact sites is well established, the interaction between mitochondria and endosomes has only recently been reported. These interactions are involved in lipid and ion transfer and potentially play a crucial role in mitochondria quality control and the release of mitochondrial components within extracellular vesicles. Here, we will discuss the current view of mitochondria-endosome interaction, both physically and functionally.

Keywords: Endocytosis; Extracellular vesicles; Lysosome; Metabolism; Mitochondria-derived vesicles; Mitochondrial dynamics.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biological Transport
  • Endocytosis*
  • Endoplasmic Reticulum / metabolism*
  • Endosomes / metabolism*
  • Humans
  • Mitochondria / metabolism*