Magnetoferritin: Process, Prospects, and Their Biomedical Applications

Int J Mol Sci. 2019 May 16;20(10):2426. doi: 10.3390/ijms20102426.


Ferritin is a spherical iron storage protein composed of 24 subunits and an iron core. Using biomimetic mineralization, magnetic iron oxide can be synthesized in the cavity of ferritin to form magnetoferritin (MFt). MFt, also known as a superparamagnetic protein, is a novel magnetic nanomaterial with good biocompatibility and flexibility for biomedical applications. Recently, it has been demonstrated that MFt had tumor targetability and a peroxidase-like catalytic activity. Thus, MFt, with its many unique properties, provides a powerful platform for tumor diagnosis and therapy. In this review, we discuss the biomimetic synthesis and biomedical applications of MFt.

Keywords: biomedical applications; ferritin; magnetic protein; magnetoferritin; tumor targeting.

Publication types

  • Review

MeSH terms

  • Animals
  • Apoferritins / metabolism*
  • Apoferritins / therapeutic use*
  • Biomechanical Phenomena
  • Contrast Media
  • Drug Delivery Systems
  • Ferric Compounds
  • Ferritins
  • Humans
  • Iron / metabolism*
  • Iron / therapeutic use*
  • Magnetic Resonance Imaging
  • Magnetite Nanoparticles
  • Neoplasms / diagnostic imaging
  • Neoplasms / drug therapy
  • Neoplasms / pathology
  • Oxides / metabolism*
  • Oxides / therapeutic use*


  • Contrast Media
  • Ferric Compounds
  • Magnetite Nanoparticles
  • Oxides
  • magnetoferritin
  • ferric oxide
  • Ferritins
  • Apoferritins
  • Iron