Fusaoctaxin A, an Example of a Two-Step Mechanism for Non-Ribosomal Peptide Assembly and Maturation in Fungi

Toxins (Basel). 2019 May 16;11(5):277. doi: 10.3390/toxins11050277.


Fungal non-ribosomal peptide synthetase (NRPS) clusters are spread across the chromosomes, where several modifying enzyme-encoding genes typically flank one NRPS. However, a recent study showed that the octapeptide fusaoctaxin A is tandemly synthesized by two NRPSs in Fusarium graminearum. Here, we illuminate parts of the biosynthetic route of fusaoctaxin A, which is cleaved into the tripeptide fusatrixin A and the pentapeptide fusapentaxin A during transport by a cluster-specific ABC transporter with peptidase activity. Further, we deleted the histone H3K27 methyltransferase kmt6, which induced the production of fusaoctaxin A.

Keywords: ABC-transporter; Fusarium; Mycotoxins; NRPS; peptidase; secondary metabolites.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Fungal Proteins / genetics
  • Fungal Proteins / metabolism*
  • Fusarium / genetics
  • Fusarium / growth & development
  • Fusarium / metabolism*
  • Histones / metabolism
  • Multigene Family
  • Peptide Synthases / genetics
  • Peptide Synthases / metabolism*
  • Peptides / genetics
  • Peptides / metabolism*
  • Triticum / microbiology


  • Fungal Proteins
  • Histones
  • Peptides
  • Peptide Synthases
  • non-ribosomal peptide synthase