Partners in Crime: Neutrophil-CTC Collusion in Metastasis

Bingqian Guo; Trudy G Oliver

doi:10.1016/j.it.2019.04.009

Partners in Crime: Neutrophil-CTC Collusion in Metastasis

Trends Immunol. 2019 Jul;40(7):556-559. doi: 10.1016/j.it.2019.04.009. Epub 2019 May 15.

Authors

Bingqian Guo¹, Trudy G Oliver²

Affiliations

¹ Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA.
² Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA. Electronic address: Trudy.Oliver@hci.utah.edu.

Abstract

A recent study in Nature (Szczerba et al. 2019;566:553-557) reports that the association of neutrophils with circulating tumor cells (CTCs) in the blood of patients with breast cancer can promote CTC proliferation and metastasis. These findings reveal a new mechanism by which the innate immune system may be co-opted to drive tumor progression.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Breast Neoplasms*
Cell Cycle
Crime
Humans
Neoplastic Cells, Circulating*
Neutrophils

Abstract

Publication types

MeSH terms

Grants and funding