Effects of weekly and daily pretreatment with gold sodium thiomalate on adjuvant induced arthritis

J Rheumatol. 1987 Apr;14(2):202-8.


The effect of gold sodium thiomalate on adjuvant induced arthritis in DA rats was investigated. Ten mg/kg gold given in either weekly or daily injections before the administration of adjuvant was able to decrease the severity of arthritis in these animals. One mg/kg gold given as daily injections had no effect on adjuvant induced arthritis. One mg/kg gold given as weekly injections before adjuvant administration reduced the severity of arthritis to a level which was intermediate between that seen in the placebo control and the 10 mg/kg gold groups. The proliferative responses of spleen cells to mitogens in these animals were not altered by in vivo gold therapy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Arthritis / chemically induced
  • Arthritis / diagnostic imaging
  • Arthritis / drug therapy*
  • Arthritis / physiopathology
  • Drug Administration Schedule
  • Female
  • Freund's Adjuvant
  • Gold Sodium Thiomalate / administration & dosage*
  • Gold Sodium Thiomalate / adverse effects
  • Gold Sodium Thiomalate / therapeutic use
  • Male
  • Radiography
  • Rats
  • Rats, Inbred Strains
  • Spleen / metabolism
  • Spleen / pathology
  • Thymidine / metabolism


  • Gold Sodium Thiomalate
  • Freund's Adjuvant
  • Thymidine