Inhibition of fibrosis in TSK mice by blocking mast cell degranulation

J Rheumatol. 1987 Apr;14(2):299-301.


The Tsk mouse has a genetically transmitted connective tissue disease whose skin lesions resemble those of scleroderma. After treatment with disodium cromoglycate, a marked decrease in skin fibrosis was observed, raising the possibility that disodium cromoglycate may be a potential treatment for human scleroderma.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cell Count
  • Cromolyn Sodium / pharmacology*
  • Cytoplasmic Granules / drug effects*
  • Fibrosis
  • Mast Cells / drug effects*
  • Mice
  • Mice, Inbred C57BL
  • Mice, Mutant Strains
  • Skin / pathology
  • Skin Abnormalities*


  • Cromolyn Sodium