Structures of Triterpenoids From the Leaves of Lansium Domesticum

J Nat Med. 2019 Sep;73(4):727-734. doi: 10.1007/s11418-019-01319-2. Epub 2019 May 18.

Abstract

From the methanolic extract of the leaves of Lansium domesticum, three new onoceranoid-type triterpenoids, lansium acids X-XII and a new cycloartane-type triterpene, lansium acid XIII, were isolated. The chemical structures of the isolated new compounds were elucidated on the basis of chemical/physicochemical evidence. For new onoceranoid-type triterpenoids, the absolute configurations were established by comparison of experimental and predicted electronic circular dichroism (ECD) data. The isolated onoceranoid-type triterpenoids showed antimutagenic effects in the Ames assay against 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1).

Keywords: Cycloartane-type triterpene; ECD; Lansium domesticum; Onoceranoid-type triterpenoid.

MeSH terms

  • Antimutagenic Agents / pharmacology*
  • Meliaceae / chemistry*
  • Molecular Structure
  • Plant Extracts / chemistry*
  • Plant Leaves
  • Triterpenes / chemistry*
  • Triterpenes / isolation & purification

Substances

  • Antimutagenic Agents
  • Plant Extracts
  • Triterpenes
  • cycloartane