Roles of GLUT-1 and HK-II expression in the biological behavior of head and neck cancer

Hang Yang; Jiang-Tao Zhong; Shui-Hong Zhou; He-Ming Han

doi:10.18632/oncotarget.24684

Roles of GLUT-1 and HK-II expression in the biological behavior of head and neck cancer

Oncotarget. 2019 Apr 30;10(32):3066-3083. doi: 10.18632/oncotarget.24684.

Authors

Hang Yang^{1

2}, Jiang-Tao Zhong¹, Shui-Hong Zhou¹, He-Ming Han¹

Affiliations

¹ Department of Otorhinolaryngology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310003, China.
² Present Address: Department of Otorhinolaryngology, The People's Hospital of Jiangshan City, Jiangshan, Zhejiang, 324100, China.

Abstract

The Warburg effect plays an important role in the proliferation and invasion of malignant tumors. Glucose transporter 1 and hexokinase II are two key energy transporters involved in mediating the Warburg effect. This review will analyze the mechanisms of these two markers in their effects on the biological behavior of head and neck cancer.

Keywords: Warburg effect; glucose transporter-1; head and neck cancer; hexokinase II.