A novel Nitrizinc Complex® solution for topical treatment of seborrhoeic keratosis: an interventional clinical study

Eur J Dermatol. 2019 Apr 1;29(2):203-208. doi: 10.1684/ejd.2019.3525.

Abstract

Seborrheic keratosis (SK) is a benign, common disease affecting mostly the middle aged and elderly population. SK lesions are characterized by pigmented skin growth, a warty surface, and sharp margins. Current therapies (curettage or cryotherapy) are invasive and painful. A non-invasive treatment is evaluated in this clinical study. Objectives: To assess the efficacy, safety, and tolerability of Nitrizinc Complex® topical solution (NZCS) for treatment of SK, after one to two topical applications. Thirty-two SK patients with a total of 59 lesions were treated with NZCS. Outcomes were determined by the dermatologist at clinical visits at one, three, six, and 12 months post-procedure and by subjective evaluation of patients through questionnaires. Six months after treatment, complete elimination was observed in 80% of the lesions (72% of the patients), while 93.3% of the lesions showed at least 50% reduction. Treatment ended with 100% cosmetic benefit as no scars or dyschromia were observed in the treated areas. Subjective treatment and cosmetic satisfaction were evaluated and corresponded to 8.66/10 and 8.07/10, respectively. The product was preferred over all other options previously used by all patients. Treatment was highly tolerable as discomfort, such as pain and itching/burning sensations, was minimal. No relapse cases have been observed at 12 months after treatment. This study demonstrates that NZCS is an efficient, easy-to-apply, safe and well tolerated treatment for SK lesions, and may therefore be considered as a potential topical non-invasive alternative for SK treatment.

Keywords: clinical study; nitric-zinc complex; non-invasive treatment; seborrheic keratosis.

Publication types

  • Clinical Study

MeSH terms

  • Acetic Acid
  • Administration, Topical
  • Copper
  • Esthetics
  • Female
  • Humans
  • Keratosis, Seborrheic / drug therapy*
  • Male
  • Nitric Acid
  • Oxalic Acid
  • Pain Measurement
  • Patient Satisfaction
  • Solutions
  • Zinc

Substances

  • Solutions
  • Nitric Acid
  • Copper
  • Oxalic Acid
  • Zinc
  • Acetic Acid