Medical-surgical Combined Approach in Perianal Fistulizing Crohn's Disease (CD): Doing it Together

Curr Drug Targets. 2019;20(13):1373-1383. doi: 10.2174/1389450120666190520103454.

Abstract

Fistulising perianal Crohn's disease (pCD) is an aggressive phenotype, and patients not only suffer from perianal manifestations but also a worsening course for their luminal disease. This article describes the 6 key steps clinicians need to consider when managing patients with pCD which include; (i) ensuring a prompt diagnosis, (ii) multi-disciplinary management, (iii) psychological support, (iv) using multimodal medical and surgical treatment strategies, (v) continually monitoring and optimising therapy and (vi) ensuring that patients have a way of accessing care if required. Patients with fistulising pCD often have an unpredictable disease course and complete remission can be elusive. As such, a considered and nuanced approach is essential keeping the wider multi-disciplinary team and the patient involved in all decision making.

Keywords: Crohn's disease; luminal disease; medical therapy; optimising therapy; perianal; surgery..

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Combined Modality Therapy / methods*
  • Crohn Disease / complications
  • Crohn Disease / therapy*
  • Disease Progression
  • Fistula / etiology
  • Fistula / therapy*
  • Humans
  • Remission Induction
  • Severity of Illness Index